The Cane River is a 30-mile-long (48 km) river in Natchitoches Parish, Louisiana, originating from a portion of the Red River. Historically, in the 19th and 20th centuries, it gained prominence as the locus of a notable Creole de couleur (multiracial) culture, centered around the National Historic Landmark, Melrose Plantation, and the adjacent St. Augustine Parish Church.